Monday, August 15, 2011

Sunitinib (Sutent) Summary

Here's a good summary of the effects and side effects of Sutent.

When it is to be taken : For gastrointestinal stromal tumor renal cell carcinoma- Adult- PO- The recommended dose is one 50 mg once daily, on a schedule of 4 weeks on treatment followed by 2 weeks off.
For pancreatic neuroendocrine tumors -The recommended dose is 37.5 mg taken orally once daily continuously without a scheduled off-treatment period.

How it should be taken : It comes as a capsule to take by mouth, with or withoutfood.

Special Instruction : 
* Caution should be exercised in patients with history of bleeding problem, chest pain, slow, fast, or irregular heartbeat,heartattack, heart failure, high blood pressure, pulmonary embolism (PE; blood clot in the lungs), transient ischemic attack (TIA) (mini-stroke), seizures, stroke,kidney, liver, or thyroid disease, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* It may cause dizziness, do not drive a car or operate machinery while taking this medication.
* It may reduce platelet counts; avoid bruising or injury.
* Avoid contact with people who have infections in order to prevent the spread of infection.
* Monitor complete blood cell counts, blood electrolytes, blood pressure checks, thyroid function, liver function, and electrocardiograms (ECG) and other heart function regularly while taking this medication.

Side Effects : 
Most Common- Fatigue, weakness, fever, diarrhea, nausea, mouth ulcer, vomiting, indigestion, abdominal pain,constipation, high blood pressure, swelling in the extremities, rash, hand-foot syndrome, skin discoloration, dry skin,haircolorchanges, altered taste, headache, back pain, joint pain, cough, difficulty in breathing, loss of appetite, and bleeding.
Gastrointestinal-Drymouth, reflux, flatulence, mouth pain, burning tongue, and piles.
Heart- High blood pressure, fluid retention, andchestpain.
Skin- Hair loss, redness, and itching.
Central Nervous System- Dizziness, depression, andsleeplessness.
Musculoskeletal- Limb discomfort.
Endocrine- Thyroid deficiency.
Respiratory- Throat pain and upper respiratory tract infection.

Read more:Sunitinib

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