For pancreatic neuroendocrine tumors -The recommended dose is 37.5 mg taken orally once daily continuously without a scheduled off-treatment period.
* Caution should be exercised in patients with history of bleeding problem, chest pain, slow, fast, or irregular heartbeat,, heart failure, high blood pressure, pulmonary embolism (PE; blood clot in the lungs), transient ischemic attack (TIA) (mini-stroke), seizures, stroke,, liver, or thyroid disease, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* It may cause dizziness, do not drive a car or operate machinery while taking this medication.
* It may reduce platelet counts; avoid bruising or injury.
* Avoid contact with people who have infections in order to prevent the spread of infection.
* Monitor complete blood cell counts, blood electrolytes, blood pressure checks, thyroid function, liver function, and electrocardiograms (ECG) and other heart function regularly while taking this medication.
Most Common- Fatigue, weakness, fever, diarrhea, nausea, mouth ulcer, vomiting, indigestion, abdominal pain,, high blood pressure, swelling in the extremities, rash, hand-foot syndrome, skin discoloration, dry skin,changes, altered taste, headache, back pain, joint pain, cough, difficulty in breathing, loss of appetite, and bleeding.
Gastrointestinal-, reflux, flatulence, mouth pain, burning tongue, and piles.
Heart- High blood pressure, fluid retention, and.
Skin- Hair loss, redness, and itching.
Central Nervous System- Dizziness, depression, and.
Musculoskeletal- Limb discomfort.
Endocrine- Thyroid deficiency.
Respiratory- Throat pain and upper respiratory tract infection.